Services

From a free consultation to custom LNP-formulated RNA, we provide a range of services catered to your project.

Our services

About mRNA Core

mRNA Core has worked with over 20 research groups across multiple Australian and international institutions to design, manufacture and analyse a diverse array of RNA products, from vaccines to gene therapies and drug delivery capabilities.

In partnership with the Monash Institute of Pharmaceutical Sciences and Therapeutic Innovation Australia, we provide multiple services across the mRNA space, utilising cutting edge technology and platforms – including Australia’s first rotating angle dynamic light scattering machine.

What we offer

Take your mRNA project to the next level

Custom mRNA

We offer the following services for custom mRNA, starting at 0.5 μg and up to 50 mg.

  • Unmodified - Native, unmodified sequences like those found naturally

  • Modified - The nucleoside uracil (U) is replaced by a synthetic analogue (m1Ψ), which better protects it from immune clearance

  • Capped - Capping with CleanCap AG at the 5’ region of the mRNA increases stability during translation processes in the cell

  • Sequence optimised - We clean up your provided sequence to optimise translation and expression of your protein

  • Specialty - Interested in something a little different? We’re always up for a challenge!

Enquire now for custom mRNA

Standard mRNA

Our off-the-shelf range is perfect for fundamental work or developing your drug delivery system.

Reporters: Non-immunogenic, great for investigating cellular expression and biological tracking.

Reporter Fluorescence Luminescence
muGFP
Ex: 488 | Em: 510		 + -
mScarlet
Ex: 569 | Em: 594		 +++ -
Firefly luciferase (FLuc)
Requires substrate for luminescence 		- +
Nanoluciferase (nLuc)
Requires substrate for luminescence		 - +++
muGFP-nLuc
Dual reporter		 + +++
mScarlet-I-nLuc
Dual reporter		 +++ +++

Antigens: Immunogenic, great to establish an immune profile or as an example application for your delivery platform.

  • Ovalbulmin (OVA)

Other: For specialised applications, such as gene therapy.

  • Cre recombinase (Cre)

Note: star rating system for mRNA reporters based on brightness (not applicable to Cre)

Enquire now for standard mRNA

Formulation

We can package your mRNA into lipid nanoparticles for optimised delivery using the following clinical formulations.

LNP Formulation In vitro performance In vivo performance
Formulation 1
Utilised for the Spikevax COVID-19 vaccine		 +++ +++
Formulation 2
Utilised for the Comirnaty COVID-19 vaccine		 + +++
Formulation 3
Utilised for the Patisiran gene therapeutic		 ++ +++
Formulation 4
Utilised for our first-in-Australia COVID-19 vaccine		 ++ +++
Enquire now for formulated mRNA

Consultation

New to mRNA technologies and not sure where to begin?

Tell us about your ideas and we can work together to design your project, and suggest the products and services best suited for you.

  • Initiation - If you have an idea for an mRNA-based project but you’ve never worked with mRNA before, we can help get you started.

  • Direction - Done a pilot study but not sure where to go next? We can provide expertise to get you on the right path.

  • Troubleshooting - Hit a wall in your project, or your own constructs aren’t performing as expected? Let us take a look under the hood and try to find a solution.

  • Helping Hand - Need some extra experimental power to elevate your project? We can suggest techniques and even perform them.

Enquire now for consultation services